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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
14.55
Human Site:
T139
Identified Species:
22.86
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
T139
Q
F
F
D
D
S
P
T
R
G
W
V
S
K
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
T139
Q
F
F
D
D
S
P
T
R
G
W
V
S
K
R
Dog
Lupus familis
XP_531814
1283
145094
K140
G
A
T
H
S
S
E
K
S
E
E
D
N
E
I
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
T139
Q
F
F
D
D
S
P
T
R
G
W
V
S
K
R
Rat
Rattus norvegicus
XP_002726765
1361
151628
G139
F
D
D
S
P
T
R
G
W
V
S
K
R
M
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
T254
Q
F
F
D
V
S
P
T
R
G
W
V
S
I
K
Frog
Xenopus laevis
NP_001089247
1340
149481
P139
T
G
A
K
Y
I
K
P
F
S
G
S
T
A
A
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
N139
P
P
T
R
G
W
V
N
T
K
Y
I
R
E
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
K62
P
K
V
K
D
G
K
K
E
A
S
K
P
A
A
Honey Bee
Apis mellifera
XP_392346
1120
127429
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
K58
V
L
K
R
S
N
S
K
T
V
S
S
P
V
K
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
T139
Q
F
G
C
K
F
H
T
T
K
P
D
V
R
R
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
E141
Q
Y
D
D
S
E
E
E
L
L
D
L
N
N
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
W139
Y
W
P
L
D
K
K
W
Y
D
G
S
V
T
F
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
N114
S
D
T
M
L
N
S
N
T
T
E
P
K
S
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
100
0
N.A.
N.A.
80
0
0
N.A.
6.6
0
0
26.6
P-Site Similarity:
100
N.A.
100
20
N.A.
100
6.6
N.A.
N.A.
86.6
6.6
20
N.A.
6.6
0
13.3
33.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
0
0
0
0
0
7
0
0
0
14
14
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
14
34
34
0
0
0
0
7
7
14
0
0
0
% D
% Glu:
0
0
0
0
0
7
14
7
7
7
14
0
0
14
7
% E
% Phe:
7
34
27
0
0
7
0
0
7
0
0
0
0
0
7
% F
% Gly:
7
7
7
0
7
7
0
7
0
27
14
0
0
0
0
% G
% His:
0
0
0
7
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
0
0
7
0
7
7
% I
% Lys:
0
7
7
14
7
7
20
20
0
14
0
14
7
20
14
% K
% Leu:
0
7
0
7
7
0
0
0
7
7
0
7
0
0
7
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
0
0
14
0
14
0
0
0
0
14
7
0
% N
% Pro:
14
7
7
0
7
0
27
7
0
0
7
7
14
0
0
% P
% Gln:
40
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
14
0
0
7
0
27
0
0
0
14
7
27
% R
% Ser:
7
0
0
7
20
34
14
0
7
7
20
20
27
7
0
% S
% Thr:
7
0
20
0
0
7
0
34
27
7
0
0
7
7
7
% T
% Val:
7
0
7
0
7
0
7
0
0
14
0
27
14
7
0
% V
% Trp:
0
7
0
0
0
7
0
7
7
0
27
0
0
0
0
% W
% Tyr:
7
7
0
0
7
0
0
0
7
0
7
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _